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Autophagy, diet and fasting

 

 

Support our work!!! Autophagy, diet and fasting: discover how to do cellular 'cleansing'

Today, in our overfed Western world, we have food at our fingertips all the time, so fasting is a choice… and not a very tempting one at first. But it may be worth it, says biochemist Laura Chiavetta, and lists its benefits: by promoting autophagy through fasting “we would be helping our body to eliminate damaged components, promote cell regeneration, keep our neurons in good condition and prevent neurodegenerative diseases; it would also have a positive impact on various liver, intestinal and heart diseases. In addition, it has been seen that another benefit of autophagy is the increase in insulin sensitivity, which would help us prevent type 2 diabetes.”

And how should we do it? Actually, it is not necessary to go too long without eating. Consider the word “breakfast.” It implies that we fast for a period of time each night, usually around eight to ten hours. Studies suggest that to enhance the beneficial effect of autophagy, it would be enough to lengthen the time between dinner and breakfast. This would be the 16/8 model, which basically consists of eating all meals within an eight-hour period, leaving the remaining sixteen hours without solid food.

This is not the only strategy: the possibility of fasting for 24 hours once a week (after consulting a doctor and a nutritionist) or of fasting for two or three days once a month (always under medical supervision) is also considered. “One option or another will depend on the type of person - recommends Dr. Durántez -. It is about finding the formula that each person finds easiest. Just as when we prescribe physical exercise to a patient, the important thing in a nutritional habit is that it is followed. It is possible that, on paper, one option is more beneficial than another, but if it is very difficult to follow, it will end up being abandoned.” 

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What exactly does fasting consist of? There is no exact guideline. As Marcos Vázquez points out, “to maximize the benefits it is best not to ingest calories and limit yourself to liquids, but there is also no great impact if we drink a little broth or add a little cream to coffee. Fat is the macronutrient that has the least impact on autophagy, since this process is more sensitive to proteins and carbohydrates. That is why it is recommended, if you are going to eat something, that it be a food with a higher fat content.” We have mentioned above the issue that fasting should be agreed upon with a doctor or nutritionist. “There are people for whom it could be counterproductive; therefore, before starting a fasting routine or calorie restriction diet, it would be prudent to first consult to assess the nutritional and general health status,” warns Laura Chiavetta. In addition, and following common sense, fasting is not recommended for people who are underweight or malnourished, or for children or pregnant and/or lactating women.

 

Autophagy

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 Autophagy

Heal without taking anything

The health and wellness industry has a new “fad”: autophagy, a scientifically recognized regenerative process of our bodies that some beauty gurus now link to weight loss, longevity and a more youthful appearance.

Autophagy is a natural regeneration mechanism that occurs in our body at the cellular level. It reduces the likelihood of contracting certain diseases and prolongs life expectancy.

In 2016, Japanese scientist Yoshinori Ohsumi won the Nobel Prize for his research into the mechanisms of autophagy, a process that remains little studied.

Their progress contributed to a greater understanding of neurodegenerative diseases such as Parkinson's and dementia.

 

Autophagy is a catabolic degradation process that occurs in a conserved manner in the lysosomes of all eukaryotic cells (and the vacuoles of yeast). The term is used to refer to the degradation of cytosolic components or parts of the cell that are “obsolete” or have stopped functioning properly.

 

 

Autophagy is a process that constantly renews our cells, preventing the accumulation of waste products and components that no longer function properly. The tools that the cell uses for this are small microscopic vesicles called autophagosomes.

These autophagosomes act in a similar way to modern domestic robot vacuum cleaners. That is, they move around the cell and “swallow” small portions of the cell, as if vacuuming up accumulated dust, converting everything they find into energy and essential molecules. This process occurs constantly, at a low intensity but sufficient to keep our cells in optimal condition, until they renew all their content over time.

Autophagy is a natural regeneration mechanism that occurs in our body at the cellular level. It reduces the likelihood of contracting certain diseases and prolongs life expectancy.

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Scientists have linked autophagy to numerous positive health effects in humans, including anti-aging and protection against degenerative diseases.

In 2016, Japanese scientist Yoshinori Ohsumi won the Nobel Prize for his research into the mechanisms of autophagy, a process that is still little studied.

His progress contributed to a better understanding of neurodegenerative diseases such as Parkinson's and dementia.Todas las células del cuerpo humano pueden verse dañadas a lo largo de su vida. 

When this happens, they have small vesicles that move around inside them and are responsible for removing the affected components, converting them into energy and other essential molecules.

This process is activated constantly, but at a low intensity. However, it is enough to keep the cells in good condition and renew them periodically.

 

 

 

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 Autofagia

Curarse sin tomar nada

La industria de la salud y el bienestar tiene una nueva "última moda": la autofagia, un proceso regenerativo de nuestro cuerpo, científicamente reconocido, que algunos gurús de la belleza vinculan ahora con la pérdida de peso, la longevidad y una apariencia más joven.

La autofagia es un mecanismo natural de regeneración que ocurre en nuestro cuerpo a nivel celular. Reduce la probabilidad de contraer ciertas enfermedades y prolonga la esperanza de vida.

En 2016 el científico japonés Yoshinori Ohsumi ganó el premio Nobel por su investigación sobre los mecanismos de la autofagia, un proceso todavía poco estudiado.

Su progreso contribuyó a un mayor entendimiento sobre enfermedades neurodegenerativas como el Parkinson o la demencia.

 

La autofagia es un proceso catabólico de degradación que ocurre de manera conservada en los lisosomas de todas las células eucariotas (y las vacuolas de las levaduras). El vocablo se utiliza para referirse a la degradación de los componentes del citosol o las partes de la célula que son “obsoletas”, o que han dejado de funcionar correctamente.

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La autofagia es un proceso que renueva nuestras células de forma constante, evitando que se acumulen productos de deshecho y componentes que ya no funcionan bien. Las herramientas que la célula utiliza para ello son unas pequeñas vesículas microscópicas llamadas autofagosomas.

Estos autofagosomas actúan de forma parecida a como lo hacen los modernos robots aspiradores domésticos. Es decir, se mueven por el interior celular y “engullen”, como si aspiraran el polvo acumulado, pequeñas porciones de la célula, convirtiendo todo lo que encuentran en energía y moléculas esenciales. Este proceso ocurre de forma constante, a una intensidad baja pero suficiente para mantener nuestras células en óptimas condiciones. Hasta llegar a renovar todo su contenido a lo largo del tiempo.

 La autofagia es un mecanismo natural de regeneración que ocurre en nuestro cuerpo a nivel celular. Reduce la probabilidad de contraer ciertas enfermedades y prolonga la esperanza de vida.

 

 

Los científicos han relacionado la autofagia con numerosos efectos positivos para la salud en los humanos, entre los que destacan el antienvejecimiento y la protección frente a las enfermedades degenerativas

En 2016 el científico japonés Yoshinori Ohsumi ganó el premio Nobel por su investigación sobre los mecanismos de la autofagia, un proceso todavía poco estudiado.

Su progreso contribuyó a un mayor entendimiento sobre enfermedades neurodegenerativas como el Parkinson o la demencia.

Todas las células del cuerpo humano pueden verse dañadas a lo largo de su vida. Cuando esto sucede, cuentan con unas pequeñas vesículas que se mueven por su interior y se encargan de retirar los componentes afectados, convirtiéndolos en energía y otras moléculas esenciales.

Este proceso está activado de forma constante, pero a baja intensidad. De todos modos, es suficiente para mantener las células en buenas condiciones e ir renovándolas de forma periódica.

 

 

 

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